Identification of new therapeutic targets in chronic liver disease

This line explores the pathogenesis of non-alcoholic fatty liver disease (NAFLD), and especially fibrosis, with the aims of determining the mechanisms that contribute to the progression of the disease and identifying new pharmacological targets for its treatment. Within the pathogenesis of chronic liver damage, we focus on the processes of fibrogenesis and hepatic regeneration, analysing in particular the role played by the different populations of hepatic cells (especially hepatocytes, stellate cells and Kupffer cells), and the signalling pathways involved in these processes.