Selección de artículos anteriores

• Blas-García A, Martí-Rodrigo A, Victor VM, Polo M, Alegre F, Funes HA, Apostolova N, Esplugues JV. The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction. J Antimicrob Chemother. 2016 Apr;71(4):916-26. doi: 10.1093/jac/dkv424. PubMed PMID: 26747094
• Polo M, Alegre F, Funes HA, Blas-Garcia A, Victor VM, Esplugues JV, Apostolova N. Mitochondrial (dys)function – a factor underlying the variability of efavirenz-induced hepatotoxicity? Br J Pharmacol. 2015 Apr;172(7):1713-27. doi: 10.1111/bph.13018. PubMed PMID: 25411110; PubMed Central PMCID: PMC4376451.
• Apostolova N, Funes HA, Blas-Garcia A, Alegre F, Polo M, Esplugues JV. Involvement of nitric oxide in the mitochondrial action of efavirenz: a differential effect on neurons and glial cells. J Infect Dis. 2015 Jun 15;211(12):1953-8. doi: 10.1093/infdis/jiu825. PubMed PMID: 25538272.
• Miova B, Dinevska-Kjovkarovska S, Esplugues JV, Apostolova N. Heat Stress Induces Extended Plateau of Hsp70 Accumulation–A Possible Cytoprotection Mechanism in Hepatic Cells. J Cell Biochem. 2015 Oct;116(10):2365-74. doi: 10.1002/jcb.25187. PubMed PMID: 25857363.
• Funes HA, Blas-Garcia A, Esplugues JV, Apostolova N. Efavirenz alters mitochondrial respiratory function in cultured neuron and glial cell lines. J Antimicrob Chemother. 2015 Aug;70(8):2249-54. doi: 10.1093/jac/dkv098. PubMed PMID: 25925594.
• Apostolova N, Funes HA, Blas-Garcia A, Galindo MJ, Alvarez A, Esplugues JV. Efavirenz and the CNS: what we already know and questions that need to be answered. J Antimicrob Chemother. 2015 Oct;70(10):2693-708. Review. doi: 10.1093/jac/dkv183. PubMed PMID: 26203180.
• Victor VM, Rovira-Llopis S, Bañuls C, Diaz-Morales N, Lopez-Domenech S, Escribano-López I, Rios-Navarro C, Alvarez A, Gomez M, Rocha M, Hernandez-Mijares A. Metformin modulates human leukocyte/endothelial cell interactions and proinflammatory cytokines in polycystic ovary syndrome patients. Atherosclerosis. 2015 Sep;242(1):167-73. doi: 10.1016/j.atherosclerosis.2015.07.017. Epub 2015 Jul 10. PubMed PMID: 26188541.
• Victor VM, Rovira-Llopis S, Saiz-Alarcón V, Sangüesa MC, Rojo-Bofill L, Bañuls C, de Pablo C, Álvarez Á, Rojo L, Rocha M, Hernández-Mijares A. Involvement of leucocyte/endothelial cell interactions in anorexia nervosa. Eur J Clin Invest. 2015 Jul;45(7):670-8. doi: 10.1111/eci.12454. Epub 2015 Jun 1. PubMed PMID: 25944525.
• Ríos-Navarro C, de Pablo C, Collado-Diaz V, Orden S, Blas-Garcia A, Martínez-Cuesta MÁ, Esplugues JV, Alvarez A. Differential effects of anti-TNF-α and anti-IL-12/23 agents on human leukocyte-endothelial cell interactions. Eur J Pharmacol. 2015 Oct 15;765:355-65. doi: 10.1016/j.ejphar.2015.08.054. PubMed PMID: 26344475.
• Apostolova N, Victor VM. Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications. Antioxid Redox Signal. 2015 Mar10;22(8):686-729. doi: 10.1089/ars.2014.5952. Review. PubMed PMID: 25546574;PubMed Central PMCID: PMC4350006.
• Hernández C, Barrachina MD, Cosín-Roger J, Ortiz-Masiá D, Alavarez A, Terradéz L, Nicolau MJ, Alós R, Esplugues JV, Calatayud S. Progastrin represses the alternative activation of human macrophages and modulates their influence on colon cancer epithelial cells. PLoSOne. 2014 Jun 5;9(6):e98458.
• Orden S, De Pablo C, Rios-Navarro C, Martinez-Cuesta MA, Peris JE, Barrachina MD, Esplugues JV, Alvarez A. Efavirenz induces interactions between leucocytes and endothelium through the activation of Mac-1 and gp150,95. J Antimicrob Chemother. 2014 Apr;69(4):995-1004.
• Ortiz-Masiá D, Cosín-Roger J, Calatayud S, Hernández C, Alós R, Hinojosa J, Apostolova N, Alvarez A, Barrachina MD. Hypoxic macrophages impair autophagy in epithelial cells through Wnt1: relevance in IBD. Mucosal Immunol. 2014 Jul;7(4):929-38. doi: 10.1038/mi.2013.108. Epub 2013 Dec 4. PubMed PMID:24301659.
• Apostolova N, Funes HA, Blas-Garcia A, Alegre F, Polo M, Esplugues JV. Involvement of Nitric Oxide in the Mitochondrial Action of Efavirenz: A Differential Effect on Neurons and Glial Cells. J Infect Dis. 2014 Dec 23. pii: jiu825. [Epub ahead of print] PubMed PMID: 25538272.
• Blas-García A, Polo M, Alegre F, Funes H, Martínez E, Apostolova N, Esplugues JV. Lack of mitochondrial toxicity of darunavir, raltegravir and rilpivirine in neurons and hepatocytes: a comparison with efavirenz. Journal of Antimicrobial Chemotherapy 2014 Nov;69(11):2995-3000.
• Calvet X, Esplugues JV. How to compare biologic drugs. Reumatol Clin. 2014 Nov-Dec;10(6):353-9. Review. 
• Funes HA, Apostolova N, Alegre F, Blas-García A, Alvarez A, Martí-Cabrera M, Esplugues JV. Neuronal bioenergetics and acute mitochondrial dysfunction: a clue to understanding the central nervous system side effects of Efavirenz. J Infect Dis. 2014 Nov 1;210(9):1385-95.
• Apostolova N, Rocha M, Rovira-Llopis S, Banuls C, Falcon R, Castello R, Hernandez-Mijares A, Victor VM. Mitochondria-targeted antioxidants as a therapeutic strategy for protecting endothelium in cardiovascular diseases. Curr Med Chem. 2014;21(25):2989-3006. PubMed PMID: 24934349.
• Rovira-Llopis S, Bañuls C, Apostolova N, Morillas C, Hernandez-Mijares A, Rocha M, Victor VM. Is glycemic control modulating endoplasmic reticulum stress in leukocytes of type 2 diabetic patients? Antioxid Redox Signal. 2014 Oct 20;21(12):1759-65. doi: 10.1089/ars.2014.6030. Epub 2014 Aug 19. PubMed PMID:25000244.
• Rocha M, Apostolova N, Herance JR, Rovira-Llopis S, Hernandez-Mijares A, Victor VM. Perspectives and potential applications of mitochondria-targeted antioxidants in cardiometabolic diseases and type 2 diabetes. Med Res Rev. 2014 Jan;34(1):160-89. doi: 10.1002/med.21285. Epub 2013 May 3. Review. PubMed PMID:23650093.
• Cosín-Roger J, Ortiz-Masiá D, Calatayud S, Hernández C, Alvarez A, Hinojosa J,Esplugues JV, Barrachina MD. M2 macrophages activate WNT signaling pathway in epithelial cells: relevance in ulcerative colitis. PLoSOne. 2013 Oct 22;8(10):e78128. doi: 10.1371/journal.pone.0078128. eCollection 2013. PubMed PMID: 24167598; PubMed Central PMCID: PMC3805515.
• De Pablo C, Orden S, Peris JE, Barrachina MD, Esplugues JV, Alvarez A. Profile of leukocyte-endothelial cell interactions induced in venules and arterioles by nucleoside reverse-transcriptase inhibitors in vivo. J Infect Dis. 2013 Nov 1;208(9):1448-53. doi: 10.1093/infdis/jit340. Epub 2013 Aug 1. PubMed PMID:23908487.
• Apostolova N, Gomez-Sucerquia LJ, Alegre F, Funes HA, Victor VM, Barrachina MD, Blas-Garcia A, Esplugues JV. ER stress in human hepatic cells treated with Efavirenz: mitochondria again. J Hepatol. 2013 Oct;59(4):780-9. doi: 10.1016/j.jhep.2013.06.005. Epub 2013 Jun 17. PubMed PMID: 23792026.
• De Pablo C, Orden S, Calatayud S, Martí-Cabrera M, Esplugues JV, Alvarez A. Differential effects of tenofovir/emtricitabine and abacavir/lamivudine on human leukocyte recruitment. Antivir Ther. 2012;17(8):1615-9. doi: 10.3851/IMP2357. Epub 2012 Sep 7. PubMed PMID: 22954798.
• Ortiz-Masià D, Díez I, Calatayud S, Hernández C, Cosín-Roger J, Hinojosa J, Esplugues JV, Barrachina MD. Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process. PLoSOne. 2012;7(10):e48535. doi: 10.1371/journal.pone.0048535. Epub 2012 Oct 31. PubMed PMID: 23119050; PubMed Central PMCID: PMC3485304.
• Garcia-Bou R, Rocha M, Apostolova N, Herance R, Hernandez-Mijares A, Victor VM. Evidence for a relationship between mitochondrial Complex I activity and mitochondrial aldehyde dehydrogenase during nitroglycerin tolerance: effects of mitochondrial antioxidants. Biochim Biophys Acta. 2012 May;1817(5):828-37. doi: 10.1016/j.bbabio.2012.02.013. Epub 2012 Feb 17. PubMed PMID: 22366168.
• Martínez-Martín N, Blas-García A, Morales JM, Marti-Cabrera M, Monleón D, Apostolova N. Metabolomics of the effect of AMPK activation by AICAR on human umbilical vein endothelial cells. Int J Mol Med. 2012 Jan;29(1):88-94. doi:10.3892/ijmm.2011.802. Epub 2011 Sep 28. PubMed PMID: 21956774.
• KlionskyDJ, …., Apostolova N,…. Zuckerbraun B. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr;8(4):445-544. PubMed PMID: 22966490; PubMed Central PMCID:PMC3404883.
• Gomez-Sucerquia LJ, Blas-Garcia A, Marti-Cabrera M, Esplugues JV, Apostolova N. Profile of stress and toxicity gene expression in human hepatic cells treated with Efavirenz. Antiviral Res. 2012 Jun;94(3):232-41. doi:10.1016/j.antiviral.2012.04.003. Epub 2012 Apr 24. PubMed PMID: 22554935.
• Menchón C, Martín R, Apostolova N, Victor VM, Alvaro M, Herance JR, García H. Gold nanoparticles supported on nanoparticulate ceria as a powerful agent against intracellular oxidative stress. Small. 2012 Jun 25;8(12):1895-903. doi:10.1002/smll.201102255. Epub 2012 Mar 27. PubMed PMID: 22454217.
• Riaño A, Ortiz-Masià D, Velázquez M, Calatayud S, Esplugues JV, Barrachina MD. Nitric oxide induces HIF-1α stabilization and expression of intestinal trefoil factor in the damaged rat jejunum and modulates ulcer healing. J Gastroenterol. 2011 May;46(5):565-76. doi: 10.1007/s00535-011-0374-1. Epub 2011 Feb 9. PubMed PMID: 21305324.
• Blas-Garcia A, Apostolova N, Esplugues JV. Oxidative stress and mitochondrial impairment after treatment with anti-HIV drugs: clinical implications. Curr Pharm Des. 2011 Dec 1;17(36):4076-86. Review. PubMed PMID: 22188456.
• Apostolova N, Blas-Garcia A, Esplugues JV. Mitochondria sentencing about cellular life and death: a matter of oxidative stress. Curr Pharm Des. 2011 Dec 1;17(36):4047-60. Review. PubMed PMID: 22188454.
• Apostolova N, Gomez-Sucerquia LJ, Gortat A, Blas-Garcia A, Esplugues JV. Autophagy as a rescue mechanism in efavirenz-induced mitochondrial dysfunction: a lesson from hepatic cells. Autophagy. 2011 Nov;7(11):1402-4. doi:10.4161/auto.7.11.17653. Epub 2011 Nov 1. PubMed PMID: 21997370.
• Apostolova N, Blas-García A, Esplugues JV. Mitochondrial interference by anti-HIV drugs: mechanisms beyond Pol-γ inhibition. Trends Pharmacol Sci. 2011 Dec;32(12):715-25. doi: 10.1016/j.tips.2011.07.007. Epub 2011 Sep 6. Review. PubMed PMID: 21899897.
• Apostolova N, Garcia-Bou R, Hernandez-Mijares A, Herance R, Rocha M, Victor VM. Mitochondrial antioxidants alleviate oxidative and nitrosative stress in a cellular model of sepsis. Pharm Res. 2011 Nov;28(11):2910-9. doi:10.1007/s11095-011-0528-0. Epub 2011 Jul 23. PubMed PMID: 21786065.
• Apostolova N, Blas-García A, Esplugues JV. Mitochondrial toxicity in HAART: an overview of in vitro evidence. Curr Pharm Des. 2011;17(20):2130-44. Review. PubMed PMID: 21718249.
• Apostolova N. Mitochondria as a pharmacological target: a clue for efficacy and a reason for toxicity. Curr Pharm Des. 2011;17(20):1984-5. PubMed PMID:21718243.
• Apostolova N, Gomez-Sucerquia LJ, Gortat A, Blas-Garcia A, Esplugues JV. Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival-promoting autophagy. Hepatology. 2011 Sep 2;54(3):1009-19. doi: 10.1002/hep.24459. Epub 2011 Aug 2. PubMed PMID: 21626526.
• Blas-Garcia A, Esplugues JV, Apostolova N. Twenty years of HIV-1 non-nucleoside reverse transcriptase inhibitors: time to reevaluate their toxicity. Curr Med Chem. 2011;18(14):2186-95. Review. PubMed PMID: 21521162.
• Hernandez-Mijares A, Rocha M, Apostolova N, Borras C, Jover A, Bañuls C, SolaE, Victor VM. Mitochondrial complex I impairment in leukocytes from type 2 diabetic patients. Free Radic Biol Med. 2011 May 15;50(10):1215-21. doi:10.1016/j.freeradbiomed.2011.01.019. Epub 2011 Jan 22. Erratum in: Free Radic Biol Med. 2015 Jul;84:386. PubMed PMID: 21262346.
• Ortiz-Masiá D, Hernández C, Quintana E, Velázquez M, Cebrián S, Riaño A, Calatayud S, Esplugues JV, Barrachina MD. iNOS-derived nitric oxide mediates the increase in TFF2 expression associated with gastric damage: role of HIF-1. FASEB J. 2010 Jan;24(1):136-45. doi: 10.1096/fj.09-137489. Epub 2009 Sep 9. PubMed PMID: 19741170.
• Apostolova N, Gomez-Sucerquia LJ, Moran A, Alvarez A, Blas-Garcia A, Esplugues JV. Enhanced oxidative stress and increased mitochondrial mass during efavirenz-induced apoptosis in human hepatic cells. Br J Pharmacol. 2010 Aug;160(8):2069-84. doi: 10.1111/j.1476-5381.2010.00866.x.PubMed PMID: 20649602;PubMed Central PMCID: PMC2958650.
• De Pablo C, Orden S, Apostolova N, Blanquer A, Esplugues JV, Alvarez A. Abacavir and didanosine induce the interaction between human leukocytes and endothelial cells through Mac-1 upregulation. AIDS. 2010 Jun 1;24(9):1259-66.doi: 10.1097/QAD.0b013e32833a2b02. PubMed PMID: 20453628.
• Díez I, Calatayud S, Hernández C, Quintana E, O’Connor JE, Esplugues JV,Barrachina MD. Nitric oxide, derived from inducible nitric oxide synthase, decreases hypoxia inducible factor-1alpha in macrophages during aspirin-induced mesenteric inflammation. Br J Pharmacol. 2010 Apr;159(8):1636-45. doi:10.1111/j.1476-5381.2010.00654.x.Epub 2010 Mar 8. PubMed PMID: 20233223; PubMed Central PMCID: PMC2925487.
• Martín R, Menchón C, Apostolova N, Victor VM, Alvaro M, Herance JR, García H. Nano-jewels in biology. Gold and platinum on diamond nanoparticles as antioxidant systems against cellular oxidative stress. ACS Nano. 2010 Nov 23;4(11):6957-65.doi: 10.1021/nn1019412. Epub 2010 Oct 12. PubMed PMID: 20939514.
• Rocha M, Apostolova N, Hernandez-Mijares A, Herance R, Victor VM. Oxidative stress and endothelial dysfunction in cardiovascular disease: mitochondria-targeted therapeutics. Curr Med Chem. 2010;17(32):3827-41. Review. PubMed PMID: 20858217.
• Blas-García A, Apostolova N, Ballesteros D, Monleón D, Morales JM, Rocha M,Victor VM, Esplugues JV. Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells. Hepatology. 2010 Jul;52(1):115-25. doi:10.1002/hep.23647. PubMed PMID: 20564379.
• Victor VM, Apostolova N, Herance R, Hernandez-Mijares A, Rocha M. Oxidative stress and mitochondrial dysfunction in atherosclerosis: mitochondria-targeted antioxidants as potential therapy. Curr Med Chem. 2009;16(35):4654-67. Review. PubMed PMID: 19903143.
• Ibiza S, Alvarez A, Romero W, Barrachina MD, Esplugues JV, Calatayud S. Gastrin induces the interaction between human mononuclear leukocytes and endothelial cells through the endothelial expression of P-selectin and VCAM-1. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1588-95. doi:10.1152/ajpcell.00082.2009. Epub 2009 Oct 7. PubMed PMID: 19812370.
• Hernández C, Santamatilde E, McCreath KJ, Cervera AM, Díez I, Ortiz-Masiá D,Martínez N, Calatayud S, Esplugues JV, Barrachina MD. Induction of trefoil factor (TFF)1, TFF2 and TFF3 by hypoxia is mediated by hypoxia inducible factor-1:implications for gastric mucosal healing. Br J Pharmacol. 2009 Jan;156(2):262-72.doi: 10.1111/j.1476-5381.2008.00044.x. Epub 2008 Dec 9. PubMed PMID: 19076725;PubMed Central PMCID: PMC2697836.
• Alvarez A, Ibiza S, Hernández C, Alvarez-Barrientos A, Esplugues JV, Calatayud S. Gastrin induces leukocyte-endothelial cell interactions in vivo and contributes to the inflammation caused by Helicobacter pylori. FASEB J. 2006 Nov;20(13):2396-8. Epub 2006 Oct 2. PubMed PMID: 17015411.
• Quintana E, Barrachina MD, Esplugues JV. Nitrergic modulation of gastrointestinal function during early endotoxemia. Curr Pharm Des. 2006;12(34):4525-35. Review. PubMed PMID: 17168758.
• Apostolova N, Cervera AM, Victor VM, Cadenas S, Sanjuan-Pla A,Alvarez-Barrientos A, Esplugues JV, McCreath KJ. Loss of apoptosis-inducing factor leads to an increase in reactive oxygen species, and an impairment of respiration that can be reversed by antioxidants. Cell Death Differ. 2006 Feb;13(2):354-7. PubMed PMID: 16195738.
• Quintana E, Hernández C, Moran AP, Esplugues JV, Barrachina MD. Transcriptional up-regulation of nNOS in the dorsal vagal complex during low endotoxemia. LifeSci. 2005 Jul 15;77(9):1044-54. PubMed PMID: 15935400.
• Quintana E, Hernández C, Alvarez-Barrientos A, Esplugues JV, Barrachina MD. Synthesis of nitric oxide in postganglionic myenteric neurons during endotoxemia: implications for gastric motor function in rats. FASEB J. 2004 Mar;18(3):531-3.Epub 2004 Jan 8. PubMed PMID: 14715697.
• Calatayud S, Barrachina MD, Quintana E, Ibiza S, Esplugues JV. Endotoxin stimulates fecal pellet output in rats through a neural mechanism. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jan;367(1):51-5. Epub 2002 Nov 12. PubMed PMID: 12616341.
• Quintana E, García-Zaragozá E, Martínez-Cuesta MA, Calatayud S, Esplugues JV,Barrachina MD. A cerebral nitrergic pathway modulates endotoxin-induced changes in gastric motility. Br J Pharmacol. 2001 Sep;134(2):325-32. PubMed PMID:11564650; PubMed Central PMCID: PMC1572955.
• Calatayud S, Barrachina MD, García-Zaragozá E, Quintana E, Esplugues JV. Endotoxin inhibits gastric emptying in rats via a capsaicin-sensitive afferent pathway. Naunyn Schmiedebergs Arch Pharmacol. 2001 Mar;363(3):276-80. PubMed PMID: 11284441.
• Barrachina MD, Panés J, Esplugues JV. Role of nitric oxide in gastrointestinal inflammatory and ulcerative diseases: perspective for drugs development. Curr Pharm Des. 2001 Jan;7(1):31-48. Review. PubMed PMID: 11172700.
• García-Zaragozá E, Barrachina MD, Moreno L, Esplugues JV. Role of central glutamate receptors, nitric oxide and soluble guanylyl cyclase in the inhibition by endotoxin of rat gastric acid secretion. Br J Pharmacol. 2000 Jul;130(6):1283-8. PubMed PMID: 10903967; PubMed Central PMCID: PMC1572196.
• Calatayud S, García-Zaragozá E, Hernández C, Quintana E, Felipo V, Esplugues JV, Barrachina MD. Down regulation of nNOS and synthesis of PGs associated with endotoxin-induced delay in gastric emptying. Am J Physiol Gastrointest Liver Physiol. 2002 Dec;283(6):G1360-7. PubMed PMID: 12433667.