Artículos recientes

• Ortiz-Masiá D, Gisbert-Ferrándiz L, Bauset C, Coll S, Mamie C, Scharl M, Esplugues JV, Alós R, Navarro F, Cosín-Roger J, Barrachina MD, Calatayud S. Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development. Cells. 2020 Apr 29;9(5). pii: E1104. doi: 10.3390/cells9051104. PubMed PMID: 32365557.
• García-Martínez P, Collado-Díaz V, Mateu-Puchades A, Villarroel-Vicente C, Rovira-Llopis S, Blas-García A, Álvarez Á, Esplugues JV, Andújar I. Differential effects of biologics on psoriasis-related vascular inflammation and risk of thrombosis. J Invest Dermatol. 2020 Apr 17. pii: S0022-202X(20)31369-5. doi: 10.1016/j.jid.2020.02.039. [Epub ahead of print] PubMed PMID: 32311396.
• Gruevska A, Moragrega AB, Galindo MJ, Esplugues JV, Blas-Garcia A, Apostolova N. p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to NNRTI. Antiviral Res. 2020 Apr 6:104784. doi: 10.1016/j.antiviral.2020.104784. [Epub ahead of print] PubMed PMID: 32272174.
• Gisbert-Ferrándiz L, Cosín-Roger J, Hernández C, Macias-Ceja DC, Ortiz-Masiá D, Salvador P, Esplugues JV, Hinojosa J, Navarro F, Calatayud S, Barrachina MD. Diminished Vitamin D Receptor Protein Levels in Crohn’s Disease Fibroblasts: Effects of Vitamin D. Nutrients. 2020 Apr 1;12(4). pii: E973. doi: 10.3390/nu12040973. PubMed PMID: 32244667.
• Cosin-Roger J, Ortiz-Masià MD, Barrachina MD. Macrophages as an Emerging Source of Wnt Ligands: Relevance in Mucosal Integrity. Front Immunol. 2019 Sep 24;10:2297. doi: 10.3389/fimmu.2019.02297. eCollection 2019. Review. PubMed PMID: 31608072; PubMed Central PMCID: PMC6769121.
• Martí-Rodrigo A, Alegre F, Moragrega ÁB, García-García F, Martí-Rodrigo P, Fernández-Iglesias A, Gracia-Sancho J, Apostolova N, Esplugues JV, Blas-García A. Rilpivirine attenuates liver fibrosis through selective STAT1-mediated apoptosis in hepatic stellate cells. Gut. 2020 May;69(5):920-932. doi: 10.1136/gutjnl-2019-318372. Epub 2019 Sep 17. PubMed PMID: 31530714.
• Cosin-Roger J, Canet F, Macias-Ceja DC, Gisbert-Ferrándiz L, Ortiz-Masiá D, Esplugues JV, Alós R, Navarro F, Barrachina MD, Calatayud S. Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis. Cells. 2019 Sep 13;8(9). pii: E1078. doi: 10.3390/cells8091078. PubMed PMID: 31540207; PubMed Central PMCID: PMC6770118.
• Ortiz-Masià D, Salvador P, Macias-Ceja DC, Gisbert-Ferrándiz L, Esplugues JV, Manyé J, Alós R, Navarro-Vicente F, Mamie C, Scharl M, Cosin-Roger J, Calatayud S, Barrachina MD. WNT2b activates epithelial-mesenchymal transition through FZD4: relevance in penetrating Crohn´s disease. J Crohns Colitis. 2020 Feb 10;14(2):230-239. doi: 10.1093/ecco-jcc/jjz134.
• Martinez-Arroyo O, Gruevska A, Victor VM, González-Polo RA, Yakhine-Diop SMS, Fuentes JM, Esplugues JV, Blas-Garcia A, Apostolova N. Mitophagy in human astrocytes treated with the antiretroviral drug Efavirenz: Lack of evidence or evidence of the lack. Antiviral Res. 2019 Aug;168:36-50. doi: 10.1016/j.antiviral.2019.04.015. Epub 2019 May 8.
• Macias-Ceja DC, Ortiz-Masiá D, Salvador P, Gisbert-Ferrándiz L, Hernández C, Hausmann M, Rogler G, Esplugues JV, Hinojosa J, Alós R, Navarro F, Cosin-Roger J, Calatayud S, Barrachina MD. Succinate receptor mediates intestinal inflammation and fibrosis. Mucosal Immunol. 2019 Jan;12(1):178-187. doi: 10.1038/s41385-018-0087-3. Epub 2018 Oct 2.
• Gisbert-Ferrándiz L, Salvador P, Ortiz-Masiá D, Macías-Ceja DC, Orden S, Esplugues JV, Calatayud S, Hinojosa J, Barrachina MD, Hernández C. A Single Nucleotide Polymorphism in the Vitamin D Receptor Gene Is Associated With Decreased Levels of the Protein and a Penetrating Pattern in Crohn’s Disease. Inflamm Bowel Dis. 2018 Jun 8;24(7):1462-1470. doi: 10.1093/ibd/izy094.
• Vallecillo-Hernández J, Barrachina MD, Ortiz-Masiá D, Coll S, Esplugues JV, Calatayud S, Hernández C. Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs. Sci Rep. 2018 Feb 26;8(1):3593.
• Collado-Diaz V, Andujar I, Sanchez-Lopez A, Orden S, Blanch-Ruiz MA, Martinez-Cuesta MA, Blas-García A, Esplugues JV, Álvarez Á. Abacavir induces arterial thrombosis in a murine model. J Infect Dis. 2018 Jun 20;218(2):228-233. doi: 10.1093/infdis/jiy001.
• Perez IA, Blas-Garcia A, Carmona L, Esplugues JV. Ensuring the Consistency of Biosimilars. Curr Pharm Des. 2017;23(44):6733-6738.
• Rovira-Llopis S, Apostolova N, Bañuls C, Muntané J, Rocha M, Victor VM. Mitochondria, the NLRP3 Inflammasome, and Sirtuins in Type 2 Diabetes: New Therapeutic Targets. Antioxid Redox Signal. 2018 Sep 10;29(8):749-791. doi: 10.1089/ars.2017.7313. Epub 2018 Jan 30. Review.
• Salvador P, Macias-Ceja DC, Gisbert L, Hernández C, Bernardo D, Alos R, Navarro-Vicente F, Esplugues JV, Ortiz-Masiá D, Barrachina MD, Calatayud S. CD16 macrophages mediate fibrosis in inflammatory bowel disease. J Crohns Colitis. 2018 Apr 27;12(5):589-599. doi: 10.1093/ecco-jcc/jjx185.
• Alegre F, Moragrega ÁB, Polo M, Marti-Rodrigo A, Esplugues JV, Blas-Garcia A, Apostolova N. Role of p62/SQSTM1 beyond autophagy: a lesson learned from drug-induced toxicity in vitro. Br J Pharmacol. 2018 Feb;175(3):440-455. doi: 10.1111/bph.14093. Epub 2018 Jan 6.
• Polo M, Alegre F, Moragrega AB, Gibellini L+, Marti-Rodrigo A, Blas-Garcia A, Esplugues JV, Apostolova N. Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress. Br J Pharmacol. 2017 Sep 23. doi: 10.1111/bph.14045. [Epub ahead of print]. Colaboración con la University of Modena and Reggio Emilia, Italia.
• Apostolova N, Blas-Garcia A, Galindo MJ, Esplugues JV. Efavirenz: What is known about the cellular mechanisms responsible for its adverse effects. Eur J Pharmacol. 2017 Oct 5;812:163-173. doi: 10.1016/j.ejphar.2017.07.016. Epub 2017 Jul 8. Review.
• Alvarez A, Orden S, Andújar I, Collado-Diaz V, Núñez-Delgado S, Galindo MJ, Estrada V, Apostolova N, Esplugues JV. Cardiovascular toxicity of abacavir: a clinical controversy in need of a pharmacological explanation. AIDS. 2017 Aug 24;31(13):1781-1795.
• Macias-Ceja DC, Cosín-Roger J, Ortiz-Masiá D, Salvador P, Hernández C, Esplugues JV, Calatayud S, Barrachina MD. Autophagy stimulation prevents intestinal mucosal inflammation and ameliorates murine colitis. Br J Pharmacol 2017 2017 Aug;174(15):2501-2511.
• Alvarez A, Rios-Navarro C, Blanch-Ruiz MA, Collado-Diaz V, Andujar I, Martinez-Cuesta MA, Orden S, Esplugues JV. Abacavir induces platelet-endothelium interactions by interfering with purinergic signalling: A step from inflammation to thrombosis. Antiviral Res. 2017 May;141:179-185.
• Escribano-Lopez I, Diaz-Morales N, Rovira-Llopis S, de Marañon AM, Orden S, Alvarez A, Bañuls C, Rocha M, Murphy MP, Hernandez-Mijares A, Victor VM. The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients. Redox Biol. 2016 Dec;10:200-205. doi: 10.1016/j.redox.2016.10.017. Colaboración con University of Cambridge.
• Milián L, Peris JE, Gandía P, Andújar I, Pallardó L, Górriz JL, Blas-García A. Tenofovir-induced toxicity in renal proximal tubular epithelial cells: involvement of mitochondria. AIDS. 2017 Jul 31;31(12):1679-1684.
• Chueca E, Apostolova N, Esplugues JV, García-González MA, Lanas Á, Piazuelo E. Proton Pump Inhibitors Display Antitumor Effects in Barrett’s Adenocarcinoma Cells. Front Pharmacol. 2016 Nov 25;7:452. PubMed PMID: 27932981; PubMed Central PMCID: PMC5122752. Colaboración con el Instituto de Investigación Sanitaria Aragón, Zaragoza/Departamento de Medicina, Psiquiatría y Dermatología, Universidad de Zaragoza.
• Hicks DF, Goossens N, Blas-García A, Tsuchida T, Wooden B, Wallace MC, NietoN, Lade A, Redhead B, Cederbaum AI, Dudley JT, Fuchs BC, Lee YA, Hoshida Y, Friedman SL. Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells. Sci Rep. 2017 Mar 3;7:42563. doi: 10.1038/srep42563. PubMed PMID: 28256512; PubMed Central PMCID:PMC5335661. Colaboración con Icahn School of Medicine at Mount Sinai, Nueva York.
• Cosin-Roger J, Simmen S, Melhem H, Atrott K, Frey-Wagner I, Hausmann M, de Vallière C, Spalinger MR, Spielmann P, Wenger RH, Zeitz J, Vavricka SR, Rogler G, Ruiz PA. Hypoxia ameliorates intestinal inflammation through NLRP3/Mtor down regulation and autophagy activation. Nat Commun. 2017 Jul 24;8(1):98. Colaboración con University Hospital Zurich/University of Zurich.
• Esplugues JV, De Pablo C, Collado-Díaz V, Hernández C, Orden S, Álvarez Á. Interference with purinergic signalling: an explanation for the cardiovascular effect of abacavir? AIDS. 2016 Jun 1;30(9):1341-51.
• Macias-Ceja DC, Cosín-Roger J, Ortiz-Masiá D, Salvador P, Hernández C, Calatayud S, Esplugues JV, Barrachina MD. The flesh ethanolic extract of Hylocereus polyrhizus exerts anti-inflammatory effects and prevents murine colitis. Clin Nutr. 2016 Dec;35(6):1333-1339.
• Blas-García A, Apostolova N, Valls-Bellés V, Esplugues JV. Endoplasmic Reticulum and Mitochondria: Independent Roles and Crosstalk in Fatty Liver Diseases and Hepatic Inflammation. Curr Pharm Des. 2016;22(18):2607-18. Review.
• Miova B, Dimitrovska M, Dinevska-Kjovkarovska S, Esplugues JV, Apostolova N. The Heat Stress Response and Diabetes: More Room for Mitochondrial Implication. Curr Pharm Des. 2016;22(18):2619-39. Review. Colaboración con University «St Cyril and Methodius», Skopje (República de Macedonia).
• Ortiz-Masiá D, Cosín-Roger J, Calatayud S, Hernández C, Alós R, Hinojosa J, Esplugues JV, Barrachina MD. M1 Macrophages Activate Notch Signalling in Epithelial Cells: Relevance in Crohn’s Disease. J Crohns Colitis. 2016 May;10(5):582-92.
• Cosín-Roger J, Ortiz-Masiá D, Calatayud S, Hernández C, Esplugues JV, Barrachina MD. The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD. Mucosal Immunol. 2016 Jul;9(4):986-98.
• Hernández C, Barrachina MD, Vallecillo-Hernández J, Álvarez Á, Ortiz-Masiá D, Cosín-Roger J, Esplugues JV, Calatayud S. Aspirin-induced gastrointestinal damage is associated with an inhibition of epithelial cell autophagy. J Gastroenterol. 2016 Jul;51(7):691-701.
• de Vallière C, Cosin-Roger J, Simmen S, Atrott K, Melhem H, Zeitz J, Madanchi M, Tcymbarevich I, Fried M, Kullak-Ublick GA, Vavricka SR, Misselwitz B, Seuwen K, Wagner CA, Eloranta JJ, Rogler G, Ruiz PA. Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein-Coupled Receptor OGR1 (GPR68). Cell Mol Gastroenterol Hepatol. 2016 Jun 25;2(6):796-810. Con University Hospital Zurich/University of Zurich.
• Klionsky DJ et al., incluyendo Apostolova N, Barrachina MD, Calatayud S, and Cossarizza A. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban].
• Victor VM, Rovira-Llopis S, Bañuls C, Diaz-Morales N, Martinez de Marañon A, Rios-Navarro C, Alvarez A, Gomez M, Rocha M, Hernández-Mijares A. Insulin Resistance in PCOS Patients Enhances Oxidative Stress and Leukocyte Adhesion: Role of Myeloperoxidase. PLoSOne. 2016 Mar 23;11(3):e0151960.
• Meier R, Lutz C, Cosín-Roger J, Fagagnini S, Bollmann G, Hünerwadel A, Mamie C, Lang S, Tchouboukov A, Weber FE, Weber A, Rogler G, Hausmann M. Decreased Fibrogenesis After Treatment with Pirfenidone in a Newly Developed Mouse Model of Intestinal Fibrosis. Inflamm Bowel Dis. 2016 Mar;22(3):569-82. Colaboración con University Hospital Zurich/University of Zurich.