In our article published recentlyin the British Journal of Pharmacology, “Abacavir causes leukocyte/platelet crosstalk by neutrophil P2X7 receptor release of sLOX” we analyze the role of neutrophils–and specifically the secretomereleased by abacavir-treatedneutrophils – in the platelet activation that precedes thrombosis. We have observed that neutrophils are target cells in abacavir-induced thrombosis and that sLOX-1 could be the missing link in abacavir-associated cardiovascular risk.
