Members of our group have published a systematic review of recent clinical trials of new antifibrotic drugs with the aim of determining the most promising options and the feasibility of extending their therapeutic value as antifibrotic agents to other fibrotic conditions. https://doi.org/10.1016/j.phrs.2024.107245
In our article published recentlyin the British Journal of Pharmacology, “Abacavir causes leukocyte/platelet crosstalk by neutrophil P2X7 receptor release of sLOX” we analyze the role of neutrophils–and specifically the secretomereleased by abacavir-treatedneutrophils – in the platelet activation that precedes thrombosis. We have observed that neutrophils are target cells in abacavir-induced thrombosis and that sLOX-1 could be the missing link in abacavir-associated cardiovascular risk.
In this review, we discuss relevant recent studies of the role of autophagy in hepatic stellate cell activation.
This review studies the structure, activation pathways, and specific cellular location of P2X7R in order to analyze its biological relevance. It points to a possible allosteric modulation of this receptor by endogenous mediators, which would turn the tiny regulated ATP inputs into an activated functional P2X7R signaling, supporting the relevance of this receptor in a non-damaged tissue.
In our review in Cells we discuss the evidence regarding apoptosis of hepatocytes induced by HIV, HIV-encoded proteins, or cART.
We just published “Metabolomics as a Promising Resource Identifying Potential Biomarkers for Inflammatory Bowel Disease”.
Would you like to contribute to a special issue of Cells: Anti-HIV Therapy and Chronic Liver Diseases? Send proposals to to nadezda.apostolova@uv.es (Guest Editor) More information
In our article recently published in J Steroid Biochem Mol Biol – a collaboration with Tytgat Institute for Liver and Intestinal Research (Amsterdam UMC, University of Amsterdam), Hospital La Fe and Hospital Manises – we show that treatment with vitamin D increases levels of its receptor and attenuates the proliferation of fibroblasts in Crohn’s disease. The Vitamin D Receptor Taq I Polymorphism Is Associated With Reduced VDR and Increased PDIA3 Protein Levels in Human Intestinal Fibroblasts Fibroblast viewed through a miscroscope
Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development.
Differential effects of biologics on psoriasis-related vascular inflammation and risk of thrombosis
